A regulatory role for porphobilinogen deaminase (PBGD) in δ-aminolaevulinic acid (δ-ALA)-induced photosensitization?
نویسندگان
چکیده
منابع مشابه
5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy.
Intracellular porphyrin generation following administration of 5-aminolaevulinic acid (ALA) has been widely used in photodynamic therapy for a range of malignant and nonmalignant lesions. However, ALA is relatively hydrophilic and lacks stability at physiologic pH, limiting its bioavailability. We have investigated more lipophilic, uncharged ALA-peptide prodrugs based on phenylalanyl-ALA conjug...
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Of 100 workers exposed to lead in varying degrees, 34 had a urinary delta amino-laevulinic acid (ALA) concentration of above 0-6 mg./100 ml. and a further 35 had an ALA concentration of between 0 3 mg. and 0-6 mg./100 ml. In only 20 of the workers was the urinary porphobilinogen concentration above 0-1 mg./100 ml., two of these being above 0-2 mg./100 ml. No significant correlation was found be...
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P.Duez1, M.Hanocq and J.Dubois series of exogenous photosensitizers have been determined. For those exposure conditions in which no exogenous sensitizers Institut de Pharmacie, Service de Chimie Bioanalytique, de Toxicologie et are added, a radical-mediated mechanism of carcinogenicity, de Chimie Physique Appliquée, Université Libre de Bruxelles, CP 205/1, however, supposes endogenous sensitize...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1998
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1998.39